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In a very latest review, we reported the identification as well as the characterization of a new atypical opioid receptor with exclusive adverse regulatory Attributes to opioid peptides.one Our results confirmed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a wide-spectrum scavenger